VTE

 

HOKUSAI VTE 2017

Open label, non-inferiority study of edoxaban vs dalteparin

1050 patients

Edoxaban 60mg OD (30mg if CrCl 30-50, body weight <60kg or taking P-glycoprotein inhib)

Dalteparin 200 U/Kg for 30 days, thereafter 150 U/Kg. Dose reduced if plt count <100!

 

Primary outcome = composite of recurrent VTE or major bleeding = Edox 12.8%, Dal 13.5%

 

Edoxaban = 7.9% recurrent VTE, 6.9% major bleeding

Dalteparin = 11.3% recurrent VTE, 4.0% dalteparin