Lymphoma biology notes


Normal B cell biology


BCL2 is a transcription factor promoting proliferation. It is upregulated within the germinal centre

BCL6 is an apoptotic protein, helping cells to die naturally. It is downregulated within the germinal centre.

C-MYC, located on chromosome 8, is a ‘global’ transcription factor with roles in proliferation and cellular growth. Under normal conditions it is able to induce apoptosis.



Most lymphomas are IgM B cells and go through a number of molecular steps to maintain IgM expression, it appears to linked to malignant cell survival.

Hence why IgM MGUS behaves as lymphoplasmacytic lymphoma, where other MGUS moves to myeloma.


Germinal Centre (CD10+) Lymphomas include:

-       DLBCL

-       Burkitts (forced MYC expression with B cell receptor signaling)

-       Follicular