Translocations & Molecular markers

t (4;11) = Infantile B-ALL

t (1;19) = E2A-PBX1 translocation = B-ALL

t (11;14) = Cyclin D1 translocation = Mantle Cell Lymphoma, Myeloma

t (3;14) = Obital Marginal Zone Lymphoma

t (11;18) = Gastric MALT Marginal Zone

t (2;5) = ALK+ T-Cell lymphoma

t (5;12) = PDGFRB re-arrangement = Eosinophilic Myeloid/Lymphoid Neoplasms

t (8;9) = PCM1-JAK2 = Eosinophilic Myeloid/Lymphoid Neoplasms

t (12;21) = B-lineage ALL (approx. 10 yr old patients)

t (8;14), t(8;22), t(2;8) = Burkitt Lymphoma

8 is location of C-MYC. 14 IGH, 22 Lambda LC, 2 Kappa LC

t (14;18) = Follicular Lymphoma

t (9;22) = Philadelphia Chromosome (Commonest translocation in elderly B-ALL)

t (1;22) = Childhood Acute megaloblastic leukaemia

t (6;9) = Acute myelomonocytic leukaemia. Seen in variants with neutrophilic differentiation and multilineage dysplasia.

t (15;17) = Variant APML. The Hb is often normal or near normal.

t (16;16) = inv(16) = AML with increase in eosinophil precursors with large purple granules. Charcot-Leyden crystals.

Monosomy 7 = JMML among others

Del 4p = PDGFRA re-arrangement = Eosinophilic Myeloid/Lymphoid Neoplasms

8p11 = FGFR1 = Eosinophilic Myeloid/Lymphoid Neoplasms

MYD88 = Waldenstroms Macroglobulinaemia

CSF3R T618I = Chronic Neutrophilic Leukaemia (it is the GCSF receptor gene)

SFSB1 + JAK2 V617F combined = RARS-T

BRAF V600E = Hairy Cell Leukaemia

SET-BP1 = atypical CML