sickle - stroke prevention

 

STOP 1998

1o prevention - TCD >200cm/s --> regular transfusion prevents stroke (92% RR)

 

STOP2 2005

1o prevention - ?Can you stop transfusing --> No, the stop arm had new strokes

 

SWiTCH

2o prevention - ?Can you switch from transfusion to HU after 30 months --> No.

 

TWiTCH 2016

1o prevention - ?Transfusion + HU & eventually stop transfusion --> Yes