Note: A hodgepodge of trials, added to as I come across them at work, during teaching or whilst preparing pages for this site. Interpretation of trial results is opinion (my own or my teachers’) and is included only as a prompt to read further and not as gospel.

sickle - stroke prevention


STOP 1998

1o prevention - TCD >200cm/s --> regular transfusion prevents stroke (92% RR)


STOP2 2005

1o prevention - ?Can you stop transfusing --> No, the stop arm had new strokes



2o prevention - ?Can you switch from transfusion to HU after 30 months --> No.


TWiTCH 2016

1o prevention - ?Transfusion + HU & eventually stop transfusion --> Yes