Trauma

 

CRASH-2

Lead to widespread uptake of TXA in major haemorrhage

Death within 4 weeks of traumatic injury was reduced by 9% vs placebo

Survival advantage was seen when first dose given within 3 hours of the time of trauma

 

PROPPR

Comparison of 1:1 and 1:2 ratios of FFP:RBC in major haemorrhage

No difference in overall mortality.

 

sickle

 

TAPS

Rate of post-operative sickle cell acute chest crisis was reduced by pre-op red cell transfusion for patient undergoing low to medium risk surgery. Only a small study but significant difference seen.

ACS occurred in 27% of untransfused, compared to 3% of transfused patients.